Membrane Transporter Database for Personalized Medicine

Diseases: Obesity: Related Transporters: UCP1 (uncoupling protein 1 (mitochondrial, proton carrier)) – UCP3 (uncoupling protein 3 (mitochondrial, proton carrier))

2010-04-03T00:42:11Z

UCP1 (uncoupling protein 1 (mitochondrial, proton carrier))

Other Symbols:

SLC25A7, UCP

Disease relevance:

UCP1 -3826G allele has been found to be associated with obesity with a gender-related effect (Ramis et al., 2004).

References:

Ramis JM, González-Sánchez JL, Proenza AM, Martínez-Larrad MT, Fernández-Pérez C, Palou A, Serrano-Ríos M. The Arg64 allele of the beta 3-adrenoceptor gene but not the -3826G [...]

Diseases: Obesity: Related Transporters: CETP (cholesteryl ester transfer protein, plasma) – SLC6A4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

2010-04-02T01:12:23Z

CETP (cholesteryl ester transfer protein, plasma)

[HDLCQ10]

In diabetic obesity, CETP may have an antiatherogenic effect (MacLean et al., 2003).

References:

MacLean PS, Bower JF, Vadlamudi S, Osborne JN, Bradfield JF, Burden HW, Bensch WH, Kauffman RF, Barakat HA. Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice. Arterioscler Thromb Vasc Biol. 2003 Aug [...]

Diseases: Obesity: AQP9 (aquaporin 9)

2010-03-26T05:09:51Z

AQP9 (aquaporin 9)

[HsT17287, SSC1]

Glycerol production and its efflux from adipocytes to the liver are crucial to modulate lipid and glucose homeostasis. Aquaporin 7 (AQP7) is an aquaglyceroporin functioning as the adipose glycerol channel. Aquaporin 9 (AQP9) is the specific channel operating in the liver. AQP7 and AQP9 mediate the trafficking of glycerol from adipose and [...]