Membrane Transporter Database for Personalized Medicine

Diseases: Obesity: Aquaporin 7 (AQP7) May Be Altered

PharmTao.com — Sat, 12 Dec 2009 01:21:54 +0000

Glycerol efflux from adipocytes to the liver is crucial for lipid and glucose homeostasis. Aquaporin 7 (AQP7) is a glycerol channel serving as a gateway of glycerol release and a regulator of adipocyte metabolism.

A study done by Catalan et al. measured the gene expression of AQP7 in visceral adipose tissue (VAT) and AQP9 in liver [...]

Diseases: Obesity: ABCA1 and ABCB1

PharmTao.com — Fri, 11 Dec 2009 01:00:09 +0000

ABCA1 (ATP-binding cassette sub-family A (ABC1) member 1) is one of the most important cellular cholesterol transporters in charge of removing cholesterol from the body through cholesterol efflux. Mutations of this gene have been associated with high-density-lipoprotein (HDL) deficiency, Tangier disease and familial hypoalphalipoproteinemia.

In Chinese overweight and obese patients, the expression of ABCA1 in monocytes [...]

Gene List: Other Transporters

PharmTao.com — Thu, 10 Dec 2009 00:27:30 +0000

Transporters not included in other families:

Gene Symbol/Link; Other Symbols; Full Name; Other Names

ASNA1; ARSA-I, ARSA1, MGC3821; arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

CD68; DKFZp686M18236, GP110, SCARD1; CD68 molecule

CTNS; CTNS-LSB, PQLC4; cystinosis, nephropathic

DISP1; DISPA, DKFZp434I0428, FLJ43740, MGC104180, MGC13130, MGC16796; dispatched homolog 1 (Drosophila)

HMGCR; LDLCQ3; 3-hydroxy-3-methylglutaryl-Coenzyme A reductase

LAMP1; CD107a, LAMPA, LGP120; lysosomal-associated membrane protein 1

LAMP2; CD107b, [...]