ABCA1 Transporter: Disease Association:
Coronary Disease:
- The R219K polymorphism of ABCA1 is related with altered lipoprotein levels, and may affect the high-density lipoprotein-cholesterol (HDL-C) response to pravastatin in Chinese patients with coronary heart disease (CHD).
(Effect of R219K polymorphism of the ABCA1 gene on the lipid-lowering effect of pravastatin in Chinese patients with coronary heart disease. Li J, Wang LF, Li ZQ, Pan W. Clin Exp Pharmacol Physiol. 2009 May;36(5-6):567-70. Epub 2008 Oct 27.PMID: 19673941)
- The C69T polymorphism of ABCA1 may be related to plasma triacylglycerol and VLDL-cholesterol levels in coronary artery patients.
(Investigation of ABCA1 C69T and G-191C polymorphisms in coronary artery disease. Ergen A, Isbir S, Tekeli A, Isbir T. In Vivo. 2008 Mar-Apr;22(2):187-90.PMID: 18468402)
- R219K polymorphism of ABCA1 gene and G > C polymorphism in intron 7 of PPARA gene may have synergistic effects in influencing the risk of premature coronary artery disease (CAD).
(Synergistic effect between polymorphisms of PPARA and ABCA1 genes on the premature coronary artery disease. Balcerzyk A, Zak I, Krauze J. Acta Cardiol. 2007 Jun;62(3):233-8.PMID: 17608096)
