ABCA1 – Structure-Function Associations
Transition from dimers to higher oligomeric forms occurs during the ATPase cycle of the ABCA1 transporter. Trompier D, Alibert M, Davanture S, Hamon Y, Pierres M, Chimini G. J Biol Chem. 2006 Jul 21;281(29):20283-90. PMID: 16709568
Influence of ApoA-I structure on the ABCA1-mediated efflux of cellular lipids. Vedhachalam C, Liu L, Nickel M, Dhanasekaran P, Anantharamaiah GM, Lund-Katz S, Rothblat GH, Phillips MC. J Biol Chem. 2004 Nov 26;279(48):49931-9. PMID: 15383537
Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren’s Syndrome. Tanaka AR, Ikeda Y, Abe-Dohmae S, Arakawa R, Sadanami K, Kidera A, Nakagawa S, Nagase T, Aoki R, Kioka N, Amachi T, Yokoyama S, Ueda K. Biochem Biophys Res Commun. 2001 May 25;283(5):1019-25. PMID: 11355874
Membrane lipid domains distinct from cholesterol/sphingomyelin-rich rafts are involved in the ABCA1-mediated lipid secretory pathway. Mendez AJ, Lin G, Wade DP, Lawn RM, Oram JF. J Biol Chem. 2001 Feb 2;276(5):3158-66. Epub 2000 Nov 9. PMID: 11073951
Synthetic amphipathic helical peptides promote lipid efflux from cells by an ABCA1-dependent and an ABCA1-independent pathway. Remaley AT, Thomas F, Stonik JA, Demosky SJ, Bark SE, Neufeld EB, Bocharov AV, Vishnyakova TG, Patterson AP, Eggerman TL, Santamarina-Fojo S, Brewer HB. J Lipid Res. 2003 Apr;44(4):828-36. Epub 2003 Jan 16. PMID: 12562845
Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1. Tang C, Vaughan AM, Anantharamaiah GM, Oram JF. J Lipid Res. 2006 Jan;47(1):107-14. Epub 2005 Oct 6. PMID: 16210729
