Pathways:
PI3K/Akt signaling pathway
Host Molecules Involved:
Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt
Viral Molecules Involved:
NS1
Tissues:
Influenza A virus-infected cells
Interactions:
PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.
Mechanisms:
PI3K/Akt signaling is required for functions during infection.
The kinase activates the interferon regulatory [...]
Gene:
PRKD3
Full Name:
protein kinase D3 [Homo sapiens]
Other Symbols:
EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU
Other Names:
OTTHUMP00000126953; protein kinase C, nu; protein kinase EPK2; protein-serine/threonine kinase
Chromosome Location:
2p21
OMIMID:
607077
GeneID:
23683
Sequences:
Nucleotide
Protein
Human-Influenza Interactions:
Protein kinase C contributes to the phosphorylation of influenza PB1 and NS1 proteins, and is associated with viral RNA polymerase [...]
Gene:
ILF3
Full Name:
interleukin enhancer binding factor 3, 90kDa [Homo sapiens]
Other Symbols:
CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF90, NFAR, NFAR-1, NFAR2, TCP110, TCP80
Other Names:
M-phase phosphoprotein 4; double-stranded RNA-binding protein, 76 kD; dsRNA binding protein NFAR-2/MPP4; interleukin enhancer binding factor 3; nuclear factor associated with dsRNA; nuclear factor of activated T-cells, [...]
