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The PI3K/Akt signaling pathway supports influenza viral propagation

Pathways:

PI3K/Akt signaling pathway

Host Molecules Involved:

Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt

Viral Molecules Involved:

NS1

Tissues:

Influenza A virus-infected cells

Interactions:

PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.

Mechanisms:

PI3K/Akt signaling is required for functions during infection.
The kinase activates the interferon regulatory [...]

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