Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

PharmTao.com — Sun, 29 Nov 2009 23:43:09 +0000

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells. SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

SOCS3

PharmTao.com — Thu, 26 Nov 2009 05:07:57 +0000

Gene:

SOCS3

Full Name:

suppressor of cytokine signaling 3 [Homo sapiens]

Other Symbols:

ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3

Other Names:

STAT induced STAT inhibitor 3; cytokine-induced SH2 protein 3

Chromosome Location:

17q25.3

OMIMID:

604176

GeneID:

9021

Sequences:

Nucleotide Protein

Human-Influenza Interactions:

SOCS1 and SOCS3 regulate influenza A virus-triggered innate immune responses through inhibiting type I interferon receptor [...]