SOCS1 « Influenza Database for Personalized Medicine

Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells.
SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

Gene:

SOCS1

Full Name:

suppressor of cytokine signaling 1 [Homo sapiens]

Other Symbols:

CIS1, CISH1, JAB, SOCS-1, SSI-1, SSI1, TIP3

Other Names:

JAK binding protein; STAT induced SH3 protein 1; Tec-interacting protein 3; cytokine-inducible SH2 protein 1

Chromosome Location:

16p13.13

OMIMID:

603597

GeneID:

8651

Sequences:

Nucleotide
Protein

Human-Influenza Interactions:

SOCS1 and SOCS3 regulate influenza A virus-triggered innate immune responses through inhibiting [...]