Pathways:
PI3K/Akt signaling pathway
Host Molecules Involved:
Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt
Viral Molecules Involved:
NS1
Tissues:
Influenza A virus-infected cells
Interactions:
PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.
Mechanisms:
PI3K/Akt signaling is required for functions during infection.
The kinase activates the interferon regulatory [...]
Pathways:
Toll-like receptor (TLR) signaling pathways
Host Molecules Involved:
TLR-3 is involved in antiviral and inflammatory responses of the innate immunity in response to influenza infections.
Other Molecules:
Poly ICLC, a synthetic double stranded RNA, polyriboinosinic-poly ribocytidylic acid (Poly IC) stabilized with l-lysine (L) and carboxymethylcellulose [...]
Gene:
STAT1
Full Name:
signal transducer and activator of transcription 1, 91kDa [Homo sapiens]
Other Symbols:
DKFZp686B04100, ISGF-3, STAT91
Other Names:
OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription-1; transcription factor ISGF-3 components p91/p84
Chromosome Location:
2q32.2
OMIMID:
600555
GeneID:
6772
Sequences:
Nucleotide
Protein
Human-Influenza Interactions:
Influenza A viruses inhibit type I IFN [...]
