Pathways:
PI3K/Akt signaling pathway
Host Molecules Involved:
Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt
Viral Molecules Involved:
NS1
Tissues:
Influenza A virus-infected cells
Interactions:
PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.
Mechanisms:
PI3K/Akt signaling is required for functions during infection.
The kinase activates the interferon regulatory [...]
Gene:
PML
Full Name:
promyelocytic leukemia [Homo sapiens]
Other Symbols:
MYL, PP8675, RNF71, TRIM19
Other Names:
promyelocytic leukemia protein; promyelocytic leukemia, inducer of; tripartite motif protein TRIM19
Chromosome Location:
15q22
OMIMID:
102578
GeneID:
5371
Sequences:
Nucleotide
Protein
Human-Influenza Interactions:
PML isoforms are expressed in a serum-dependent manner, and inhibit the propagation of influenza virus at an early stage of infection.
(http://www.ncbi.nlm.nih.gov/pubmed/16154611)
