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M1 blocks the complement pathway

Pathways:

The complement pathway

Influenza Molecules Involved:

The matrix (M1) protein of influenza A virus regulates the viral life cycle.

Host Molecules Involved:

Complement C1qA

Tissues:

Lung

Systems:

Host innate immune system

Interactions:

M1 interacts with complement C1qA, inhibits the classical complement pathway.

Mechanisms:

The N-terminal domain of M1 protein is needed for binding to the globular [...]

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