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Pathways: IFN-gamma pathway Host Molecules Involved: Protease-activated receptor-2 (PAR(2)), associated with inflammation at mucosal surfaces. Tissues: Respiratory tract, mucosal surfaces, bronchoalveolar lavages Systems: Lungs, immune system Interactions: PAR(2) enhances IFN- gamma production. Mechanisms: In vitro, PAR(2) inhibits influenza virus type A (IAV) replication through the production of IFN-gamma. Pathways: The complement pathway Influenza Molecules Involved: The matrix (M1) protein of influenza A virus regulates the viral life cycle. Host Molecules Involved: Complement C1qA Tissues: Lung Systems: Host innate immune system Interactions: M1 interacts with complement C1qA, inhibits the classical complement pathway. Mechanisms: The N-terminal domain of M1 protein is needed for binding to the globular [...] Gene: RARRES3 Full Name: retinoic acid receptor responder (tazarotene induced) 3 [Homo sapiens] Other Symbols: HRASLS4, MGC8906, PLA1/2-3, RIG1, TIG3 Other Names: retinoic acid-inducible gene 1 Chromosome Location: 11q23 OMIMID: 605092 GeneID: 5920 Sequences: Nucleotide Human-Influenza Interactions: RIG-I is needed for inducing IFN-I in an influenza A virus (IAV)-infected human lung epithelial cell line. (http://www.ncbi.nlm.nih.gov/pubmed/17053203)
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