Influenza Database for Personalized Medicine » Jak/Stat http://pharmtao.com/blog4 Databases, Encyclopedia, and All Information for Influenza Prevention and Treatment Sun, 29 Nov 2009 23:43:09 +0000 http://wordpress.org/?v=2.8.6 en hourly 1 Influenza A virus inhibits IFN-gamma functions through the Jak/Stat pathway http://pharmtao.com/blog4/2009/11/28/influenza-a-virus-inhibits-ifn-gamma-functions-through-the-jakstat-pathway/ http://pharmtao.com/blog4/2009/11/28/influenza-a-virus-inhibits-ifn-gamma-functions-through-the-jakstat-pathway/#comments Sun, 29 Nov 2009 01:34:03 +0000 PharmTao.com http://pharmtao.com/blog4/?p=210 Pathways:

Jak/Stat pathway

Host Molecules Involved:

interferons (IFN), in innate immunity

Influenza Strain:

A/Aichi/2/68 (H3N2) (Aichi)

Tissues:

Respiratory epithelial cells

Interactions:

Influenza virus inhibits IFN-gamma.

Mechanisms:

Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Nuclear [...]]]> http://pharmtao.com/blog4/2009/11/28/influenza-a-virus-inhibits-ifn-gamma-functions-through-the-jakstat-pathway/feed/ 0