Pathways:
Jak/Stat pathway
Host Molecules Involved:
interferons (IFN), in innate immunity
Influenza Strain:
A/Aichi/2/68 (H3N2) (Aichi)
Tissues:
Respiratory epithelial cells
Interactions:
Influenza virus inhibits IFN-gamma.
Mechanisms:
Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression.
Nuclear [...]
