Categories

Archives

Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells.
SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

November 29th, 2009 | Tags: , , , , , , , , , , , , , , , , , | Category: Pathways | Leave a comment

Influenza A virus inhibits IFN-gamma functions through the Jak/Stat pathway

Pathways:

Jak/Stat pathway

Host Molecules Involved:

interferons (IFN), in innate immunity

Influenza Strain:

A/Aichi/2/68 (H3N2) (Aichi)

Tissues:

Respiratory epithelial cells

Interactions:

Influenza virus inhibits IFN-gamma.

Mechanisms:

Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression.
Nuclear [...]

November 28th, 2009 | Tags: , , , , , , , , , , , , , , , , | Category: Pathways | Leave a comment
 
  Older Entries »

Copyright © 2009 PharmTao.com. All Rights Reserved.
Disclaimer: By using this site, the readers agree that the content on our web pages is for information purpose only. The information provided on our web pages is not intended for diagnosis, or to treat, cure or prevent any diseases, conditions or symptoms, or to do experiments, or to endorse any products. Personal directions and the use of health and biomedical products should be provided by qualified health professionals.