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Pathways: RIG-I/MAVS/IFNAR1 pathway Host Molecules Involved: Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins Influenza Strain: Influenza A virus (IAV) Tissues: Human respiratory epithelial cells Interactions: SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway Mechanisms: SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells. Pathways: IFN-gamma pathway Host Molecules Involved: Protease-activated receptor-2 (PAR(2)), associated with inflammation at mucosal surfaces. Tissues: Respiratory tract, mucosal surfaces, bronchoalveolar lavages Systems: Lungs, immune system Interactions: PAR(2) enhances IFN- gamma production. Mechanisms: In vitro, PAR(2) inhibits influenza virus type A (IAV) replication through the production of IFN-gamma. Gene: SOCS3 Full Name: suppressor of cytokine signaling 3 [Homo sapiens] Other Symbols: ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3 Other Names: STAT induced STAT inhibitor 3; cytokine-induced SH2 protein 3 Chromosome Location: 17q25.3 OMIMID: 604176 GeneID: 9021 Sequences: Nucleotide Human-Influenza Interactions: SOCS1 and SOCS3 regulate influenza A virus-triggered innate immune responses through inhibiting type I interferon receptor [...]
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