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Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells.
SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

November 29th, 2009 | Tags: , , , , , , , , , , , , , , , , , | Category: Pathways | Leave a comment

The PI3K/Akt signaling pathway supports influenza viral propagation

Pathways:

PI3K/Akt signaling pathway

Host Molecules Involved:

Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt

Viral Molecules Involved:

NS1

Tissues:

Influenza A virus-infected cells

Interactions:

PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.

Mechanisms:

PI3K/Akt signaling is required for functions during infection.
The kinase activates the interferon regulatory [...]

November 27th, 2009 | Tags: , , , , , , , , , , , , , | Category: Pathways | Leave a comment

TNF

Gene:

TNF

Full Name:

tumor necrosis factor (TNF superfamily, member 2) [Homo sapiens]

Other Symbols:

DADB-70P7.1, DIF, TNF-alpha, TNFA, TNFSF2

Other Names:

APC1 protein; TNF superfamily, member 2; TNF, macrophage-derived; TNF, monocyte-derived; cachectin; tumor necrosis factor alpha

Chromosome Location:

6p21.3

OMIMID:

191160

GeneID:

7124

Sequences:

Nucleotide
Protein

Human-Influenza Interactions:

- In elderly individuals, antibody titer to influenza A virus was [...]

November 25th, 2009 | Tags: , , , , , , , , , , | Category: Host-Virus Interactions | Leave a comment
 
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