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Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells.
SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

November 29th, 2009 | Tags: , , , , , , , , , , , , , , , , , | Category: Pathways | Leave a comment

TNFSF10

Gene:

TNFSF10

Full Name:

tumor necrosis factor (ligand) superfamily, member 10 [Homo sapiens]

Other Symbols:

APO2L, Apo-2L, CD253, TL2, TRAIL

Other Names:

Apo-2 ligand; TNF-related apoptosis inducing ligand TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta

Chromosome Location:

3q26

OMIMID:

603598

GeneID:

8743

Sequences:

Nucleotide
Protein

Human-Influenza Interactions:

- During influenza infection, [...]

November 25th, 2009 | Tags: , , , , , , , , , | Category: Host-Virus Interactions | Leave a comment
 
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