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Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells.
SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

November 29th, 2009 | Tags: , , , , , , , , , , , , , , , , , | Category: Pathways | Leave a comment

Host-Virus (Human-Influenza) Interaction Genes: IFNAR1

Symbol:

IFNAR1

Full Name:

interferon (alpha, beta and omega) receptor 1 [Homo sapiens]

Other Symbols:

AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC

Other Names:

alpha-type antiviral protein; beta-type antiviral protein; interferon-alpha receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1

Chromosome Location:

21q22.11

OMIMID:

107450

GeneID:

3454

Sequences:

Nucleotide
Protein

Family:

Interferon

Function:

An antiviral factor; stimulates Janus protein kinases.

Human-Influenza Interactions:

In influenza A virus-infected bronchial epithelial [...]

November 24th, 2009 | Tags: , , , , , , , , , , , | Category: Host-Virus Interactions | Leave a comment

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