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Influenza A virus inhibits IFN-gamma functions through the Jak/Stat pathway

Pathways:

Jak/Stat pathway

Host Molecules Involved:

interferons (IFN), in innate immunity

Influenza Strain:

A/Aichi/2/68 (H3N2) (Aichi)

Tissues:

Respiratory epithelial cells

Interactions:

Influenza virus inhibits IFN-gamma.

Mechanisms:

Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression.
Nuclear [...]

November 28th, 2009 | Tags: , , , , , , , , , , , , , , , , | Category: Pathways | Leave a comment

Protease-activated receptor-2 protects against influenza virus through IFN-gamma pathway

Pathways:

IFN-gamma pathway

Host Molecules Involved:

Protease-activated receptor-2 (PAR(2)), associated with inflammation at mucosal surfaces.

Tissues:

Respiratory tract, mucosal surfaces, bronchoalveolar lavages

Systems:

Lungs, immune system

Interactions:

PAR(2) enhances IFN- gamma production.

Mechanisms:

In vitro, PAR(2) inhibits influenza virus type A (IAV) replication through the production of IFN-gamma.
In [...]

November 27th, 2009 | Tags: , , , , , , , , , , , , | Category: Pathways | Leave a comment

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