|
||||||
|
Pathways: RIG-I/MAVS/IFNAR1 pathway Host Molecules Involved: Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins Influenza Strain: Influenza A virus (IAV) Tissues: Human respiratory epithelial cells Interactions: SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway Mechanisms: SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells. Pathways: Jak/Stat pathway Host Molecules Involved: interferons (IFN), in innate immunity Influenza Strain: A/Aichi/2/68 (H3N2) (Aichi) Tissues: Respiratory epithelial cells Interactions: Influenza virus inhibits IFN-gamma. Mechanisms: Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Pathways: The complement pathway Influenza Molecules Involved: The matrix (M1) protein of influenza A virus regulates the viral life cycle. Host Molecules Involved: Complement C1qA Tissues: Lung Systems: Host innate immune system Interactions: M1 interacts with complement C1qA, inhibits the classical complement pathway. Mechanisms: The N-terminal domain of M1 protein is needed for binding to the globular [...]
Copyright © 2009 PharmTao.com. All Rights Reserved.
|
||||||
|
Copyright © 2010 Influenza Database for Personalized Medicine - All Rights Reserved 
|
||||||
