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Pathways: Jak/Stat pathway Host Molecules Involved: interferons (IFN), in innate immunity Influenza Strain: A/Aichi/2/68 (H3N2) (Aichi) Tissues: Respiratory epithelial cells Interactions: Influenza virus inhibits IFN-gamma. Mechanisms: Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Nutrients Green tea catechin derivatives with different alkyl chain length and aromatic ring substitutions at the 3-hydroxyl group, synthesized from epigallocatechin (EGC) and (+)-catechin (C) (Song et al., 2007). Herbs and Herbal Extracts Green tea catechin derivatives Effects and Interactions Green tea catechin derivatives have a broad spectrum activity against various subtypes of influenza [...] Nutrients Polyphenols Herbs and Herbal Extracts The aerial roots of Geranium sanguineum L. (PC) Effects and Interactions The herb may have anti-influenza effects. A polyphenol-rich extract from the aerial roots of Geranium sanguineum L. (PC) has been found to protect mice from mortality in the A/Aichi/2/68 (H3N2) influenza infection (Serkedjieva et al., 2008). At the dose of 5.4 [...]
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