Influenza Database for Personalized Medicine » epithelial

Influenza A virus inhibits IFN-gamma functions through the Jak/Stat pathway

PharmTao.com — Sun, 29 Nov 2009 01:34:03 +0000

Pathways:

Jak/Stat pathway

Host Molecules Involved:

interferons (IFN), in innate immunity

Influenza Strain:

A/Aichi/2/68 (H3N2) (Aichi)

Tissues:

Respiratory epithelial cells

Interactions:

Influenza virus inhibits IFN-gamma.

Mechanisms:

Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Nuclear [...]

TLR3

PharmTao.com — Thu, 26 Nov 2009 05:13:35 +0000

Gene:

TLR3

Full Name:

toll-like receptor 3 [Homo sapiens]

Other Symbols:

CD283

Chromosome Location:

4q35

OMIMID:

603029

GeneID:

7098

Sequences:

Nucleotide Protein

Human-Influenza Interactions:

TLR3 is expressed in human alveolar and bronchial epithelial cells, and involved in the immune response of respiratory epithelial cells to influenza A virus and dsRNA.

(http://www.ncbi.nlm.nih.gov/pubmed/15579900)

RARRES3

PharmTao.com — Thu, 26 Nov 2009 03:14:31 +0000

Gene:

RARRES3

Full Name:

retinoic acid receptor responder (tazarotene induced) 3 [Homo sapiens]

Other Symbols:

HRASLS4, MGC8906, PLA1/2-3, RIG1, TIG3

Other Names:

retinoic acid-inducible gene 1

Chromosome Location:

11q23

OMIMID:

605092

GeneID: 5920

Sequences:

Nucleotide Protein

Human-Influenza Interactions:

RIG-I is needed for inducing IFN-I in an influenza A virus (IAV)-infected human lung epithelial cell line.

(http://www.ncbi.nlm.nih.gov/pubmed/17053203)