|
||||||
|
Pathways: Jak/Stat pathway Host Molecules Involved: interferons (IFN), in innate immunity Influenza Strain: A/Aichi/2/68 (H3N2) (Aichi) Tissues: Respiratory epithelial cells Interactions: Influenza virus inhibits IFN-gamma. Mechanisms: Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Gene: TLR3 Full Name: toll-like receptor 3 [Homo sapiens] Other Symbols: CD283 Chromosome Location: 4q35 OMIMID: 603029 GeneID: 7098 Sequences: Nucleotide Human-Influenza Interactions: TLR3 is expressed in human alveolar and bronchial epithelial cells, and involved in the immune response of respiratory epithelial cells to influenza A virus and dsRNA. (http://www.ncbi.nlm.nih.gov/pubmed/15579900) Gene: RARRES3 Full Name: retinoic acid receptor responder (tazarotene induced) 3 [Homo sapiens] Other Symbols: HRASLS4, MGC8906, PLA1/2-3, RIG1, TIG3 Other Names: retinoic acid-inducible gene 1 Chromosome Location: 11q23 OMIMID: 605092 GeneID: 5920 Sequences: Nucleotide Human-Influenza Interactions: RIG-I is needed for inducing IFN-I in an influenza A virus (IAV)-infected human lung epithelial cell line. (http://www.ncbi.nlm.nih.gov/pubmed/17053203)
Copyright © 2009 PharmTao.com. All Rights Reserved.
|
||||||
|
Copyright © 2010 Influenza Database for Personalized Medicine - All Rights Reserved 
|
||||||
