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Pathways: Jak/Stat pathway Host Molecules Involved: interferons (IFN), in innate immunity Influenza Strain: A/Aichi/2/68 (H3N2) (Aichi) Tissues: Respiratory epithelial cells Interactions: Influenza virus inhibits IFN-gamma. Mechanisms: Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Gene: TLR3 Full Name: toll-like receptor 3 [Homo sapiens] Other Symbols: CD283 Chromosome Location: 4q35 OMIMID: 603029 GeneID: 7098 Sequences: Nucleotide Human-Influenza Interactions: TLR3 is expressed in human alveolar and bronchial epithelial cells, and involved in the immune response of respiratory epithelial cells to influenza A virus and dsRNA. (http://www.ncbi.nlm.nih.gov/pubmed/15579900) Gene: MIF Full Name: macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] Other Symbols: GIF, GLIF, MMIF Other Names: macrophage migration inhibitory factor; phenylpyruvate tautomerase Chromosome Location: 22q11.23 OMIMID: 153620 GeneID: 4282 Sequences: Nucleotide Human-Influenza Interactions: After influenza A virus infection, released from necrosis of lung epithelial cells. (http://www.ncbi.nlm.nih.gov/pubmed/12186913)
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