Influenza Database for Personalized Medicine » apoptosis

The PI3K/Akt signaling pathway supports influenza viral propagation

PharmTao.com — Fri, 27 Nov 2009 21:16:05 +0000

Pathways:

PI3K/Akt signaling pathway

Host Molecules Involved:

Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt

Viral Molecules Involved:

NS1

Tissues:

Influenza A virus-infected cells

Interactions:

PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.

Mechanisms:

PI3K/Akt signaling is required for functions during infection. The kinase activates the interferon regulatory [...]

Host-Virus (Human-Influenza) Interaction Genes: HDAC6

PharmTao.com — Wed, 25 Nov 2009 02:59:59 +0000

Symbol:

HDAC6

Full Name:

histone deacetylase 6 [Homo sapiens]

Other Symbols:

FLJ16239, HD6, JM21

Other Names:

OTTHUMP00000197663

Chromosome Location:

Xp11.23

OMIMID:

300272

GeneID:

10013

Sequences:

Nucleotide Protein

Family:

7-transmembrane-region receptors; protease-activated receptor family

Function:

Histone deacetylase activity, represses transcription.

Human-Influenza Interactions:

In influenza A virus (IAV)-infected cells, caspase-3 mediates cleavage of HDAC6, which removes most of C-terminal ubiquitin-binding zinc finger domain. HDAC6 may have a [...]

Host-Virus (Human-Influenza) Interaction Genes: CASP3

PharmTao.com — Tue, 24 Nov 2009 20:09:34 +0000

Symbol:

CASP3

Full Name:

caspase 3, apoptosis-related cysteine peptidase [Homo sapiens]

Other Symbols:

CPP32, CPP32B, SCA-1

Other Names:

PARP cleavage protease; SREBP cleavage activity 1; Yama; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32; procaspase3

Chromosome Location:

4q34

OMIMID:

600636

GeneID:

836

Sequences:

Nucleotide

Protein

Family:

Cysteine-aspartic acid protease (caspase) family

Function:

Cleaves, activates caspases 6, 7 and 9; [...]