Pathways:
PI3K/Akt signaling pathway
Host Molecules Involved:
Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt
Viral Molecules Involved:
NS1
Tissues:
Influenza A virus-infected cells
Interactions:
PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.
Mechanisms:
PI3K/Akt signaling is required for functions during infection.
The kinase activates the interferon regulatory [...]
Symbol:
HDAC6
Full Name:
histone deacetylase 6 [Homo sapiens]
Other Symbols:
FLJ16239, HD6, JM21
Other Names:
OTTHUMP00000197663
Chromosome Location:
Xp11.23
OMIMID:
300272
GeneID:
10013
Sequences:
Nucleotide
Protein
Family:
7-transmembrane-region receptors; protease-activated receptor family
Function:
Histone deacetylase activity, represses transcription.
Human-Influenza Interactions:
In influenza A virus (IAV)-infected cells, caspase-3 mediates cleavage of HDAC6, which removes most of C-terminal ubiquitin-binding zinc finger domain. HDAC6 may have a [...]
Symbol:
CASP3
Full Name:
caspase 3, apoptosis-related cysteine peptidase [Homo sapiens]
Other Symbols:
CPP32, CPP32B, SCA-1
Other Names:
PARP cleavage protease; SREBP cleavage activity 1; Yama; apopain; caspase 3; caspase 3, apoptosis-related cysteine protease; cysteine protease CPP32; procaspase3
Chromosome Location:
4q34
OMIMID:
600636
GeneID:
836
Sequences:
Nucleotide
Protein
Family:
Cysteine-aspartic acid protease (caspase) family
Function:
Cleaves, activates caspases 6, 7 and 9; [...]