Influenza Database for Personalized Medicine » antiviral

Toll-like receptor (TLR) agonists activate TLR signaling pathways with anti-influenza effects

PharmTao.com — Fri, 27 Nov 2009 01:10:42 +0000

Pathways:

Toll-like receptor (TLR) signaling pathways

Host Molecules Involved:

TLR-3 is involved in antiviral and inflammatory responses of the innate immunity in response to influenza infections.

Other Molecules:

Poly ICLC, a synthetic double stranded RNA, polyriboinosinic-poly ribocytidylic acid (Poly IC) stabilized with l-lysine (L) and carboxymethylcellulose [...]

TNFSF4

PharmTao.com — Thu, 26 Nov 2009 05:26:18 +0000

Gene:

TNFSF4

Full Name:

tumor necrosis factor (ligand) superfamily, member 4 [Homo sapiens]

Other Symbols:

CD134L, CD252, GP34, OX-40L, OX4OL, TXGP1

Other Names:

CD134 ligand; OX40 antigen ligand; tax-transcriptionally activated glycoprotein 1 (34kD)

Chromosome Location:

1q25

OMIMID:

603594

GeneID:

7292

Sequences:

Nucleotide Protein

Human-Influenza Interactions:

OX40L costimulates human antiviral memory CD8 T cell responses, enhances anti-influenza responses, especially in combination [...]

PTX3

PharmTao.com — Thu, 26 Nov 2009 03:12:03 +0000

Gene:

PTX3

Full Name:

pentraxin-related gene, rapidly induced by IL-1 beta [Homo sapiens]

Other Symbols:

TNFAIP5, TSG-14

Other Names:

pentaxin-related gene, rapidly induced by IL-1 beta, tumor necrosis factor, alpha-induced protein 5; pentaxin-related protein PTX3; pentraxin 3; pentraxin-3; tumor necrosis factor, alpha-induced protein 5; tumor necrosis factor-inducible protein TSG-14

Chromosome Location:

3q25

OMIMID:

602492

GeneID:

5806

Sequences:

Nucleotide Protein [...]