Influenza Database for Personalized Medicine

Innate immune response to influenza A virus infection is inhibited by SOCS1 and SOCS3 via the RIG-I/MAVS/IFNAR1-dependent pathway

PharmTao.com — Sun, 29 Nov 2009 23:43:09 +0000

Pathways:

RIG-I/MAVS/IFNAR1 pathway

Host Molecules Involved:

Eight “suppressor of cytokine signaling” (SOCS) regulatory proteins

Influenza Strain:

Influenza A virus (IAV)

Tissues:

Human respiratory epithelial cells

Interactions:

SOCS1 and SOCS3, RIG-I/MAVS/IFNAR1 pathway

Mechanisms:

SOCS1 to SOCS7 are constitutively expressed in IAV-infected cells. SOCS1 and SOCS3 expressions are up-regulated after IAV [...]

Influenza A virus inhibits IFN-gamma functions through the Jak/Stat pathway

PharmTao.com — Sun, 29 Nov 2009 01:34:03 +0000

Pathways:

Jak/Stat pathway

Host Molecules Involved:

interferons (IFN), in innate immunity

Influenza Strain:

A/Aichi/2/68 (H3N2) (Aichi)

Tissues:

Respiratory epithelial cells

Interactions:

Influenza virus inhibits IFN-gamma.

Mechanisms:

Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression. Nuclear [...]

The PI3K/Akt signaling pathway supports influenza viral propagation

PharmTao.com — Fri, 27 Nov 2009 21:16:05 +0000

Pathways:

PI3K/Akt signaling pathway

Host Molecules Involved:

Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt

Viral Molecules Involved:

NS1

Tissues:

Influenza A virus-infected cells

Interactions:

PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.

Mechanisms:

PI3K/Akt signaling is required for functions during infection. The kinase activates the interferon regulatory [...]