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Protease-activated receptor-2 protects against influenza virus through IFN-gamma pathway

Pathways:

IFN-gamma pathway

Host Molecules Involved:

Protease-activated receptor-2 (PAR(2)), associated with inflammation at mucosal surfaces.

Tissues:

Respiratory tract, mucosal surfaces, bronchoalveolar lavages

Systems:

Lungs, immune system

Interactions:

PAR(2) enhances IFN- gamma production.

Mechanisms:

In vitro, PAR(2) inhibits influenza virus type A (IAV) replication through the production of IFN-gamma.
In [...]

November 27th, 2009 | Tags: , , , , , , , , , , , , | Category: Pathways | Leave a comment

M1 blocks the complement pathway

Pathways:

The complement pathway

Influenza Molecules Involved:

The matrix (M1) protein of influenza A virus regulates the viral life cycle.

Host Molecules Involved:

Complement C1qA

Tissues:

Lung

Systems:

Host innate immune system

Interactions:

M1 interacts with complement C1qA, inhibits the classical complement pathway.

Mechanisms:

The N-terminal domain of M1 protein is needed for binding to the globular [...]

November 26th, 2009 | Tags: , , , , , , , , , , , , , | Category: Pathways | Leave a comment
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