Pathways:
Jak/Stat pathway
Host Molecules Involved:
interferons (IFN), in innate immunity
Influenza Strain:
A/Aichi/2/68 (H3N2) (Aichi)
Tissues:
Respiratory epithelial cells
Interactions:
Influenza virus inhibits IFN-gamma.
Mechanisms:
- Influenza infection suppressed IFN-gamma-caused up-regulation of HLA-DRalpha mRNA, and class II transactivator (CIITA), a mediator of MHC class II expression.
- Nuclear translocation of Stat1alpha by IFN-gamma stimulation was suppressed, related to a reduction in Tyr701 and Ser727 phosphorylation of Stat1alpha.
Effects:
Influenza A virus subverts antiviral host defense mediated by IFN-gamma through affecting the intracellular signaling Jak/Stat pathways.
Reference:
Uetani, K., Hiroi, M., et al. (2008) Influenza A virus abrogates IFN-gamma response in respiratory epithelial cells by disruption of the Jak/Stat pathway. Eur J Immunol 38, 1559-1573.
