Pathways:
PI3K/Akt signaling pathway
Host Molecules Involved:
Phosphatidylinositol-3-kinase (PI3K), the downstream effector protein kinase Akt
Viral Molecules Involved:
NS1
Tissues:
Influenza A virus-infected cells
Interactions:
PI3K is activated through direct interaction with A/NS1, via the p85 regulatory subunit.
Mechanisms:
- PI3K/Akt signaling is required for functions during infection.
- The kinase activates the interferon regulatory factor-3 during antiviral interferon induction, with virus supportive functions.
- PI3K regulates an early step during viral entry, results in inhibition of premature apoptosis at later stages of infection.
Effects:
PI3K signaling pathway supports viral propagation.
Reference:
Ehrhardt, C. and Ludwig, S. (2009) A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway. Cell Microbiol 11, 863-871.
