Host-Virus (Human-Influenza) Interaction Genes: IFNB1

Symbol:

IFNB1

Full Name:

interferon, beta 1, fibroblast [Homo sapiens]

Other Symbols:

IFB, IFF, IFNB, MGC96956

Other Names:

interferon beta

Chromosome Location:

9p21

OMIMID:

147640

GeneID:

3456

Sequences:

• Nucleotide
• Protein

Family:

Interferon

Human-Influenza Interactions:

- After influenza virus infection, strong tissue-specific induction of IFN-beta gene keeps immune cells in activated state.

(http://www.ncbi.nlm.nih.gov/pubmed/19667093)

- Influenza A viruses inhibit IFNbeta gene induction, and suppress type I IFN signaling, with the SOCS-3 protein involved.

(http://www.ncbi.nlm.nih.gov/pubmed/18989459)

- Influenza B virus nonstructural protein (NS1) acts as a beta interferon antagonist.

(http://www.ncbi.nlm.nih.gov/pubmed/14747551)

- The NS1 of influenza A virus binds to RIG-I, inhibiting downstream activation of IRF-3, and blocking the transcriptional induction of IFN-beta.

(http://www.ncbi.nlm.nih.gov/pubmed/17079289)