Host-Virus (Human-Influenza) Interaction Genes: HDAC6

Symbol:

HDAC6

Full Name:

histone deacetylase 6 [Homo sapiens]

Other Symbols:

FLJ16239, HD6, JM21

Other Names:

OTTHUMP00000197663

Chromosome Location:

Xp11.23

OMIMID:

300272

GeneID:

10013

Sequences:

• Nucleotide
• Protein

Family:

7-transmembrane-region receptors; protease-activated receptor family

Function:

Histone deacetylase activity, represses transcription.

Human-Influenza Interactions:

In influenza A virus (IAV)-infected cells, caspase-3 mediates cleavage of HDAC6, which removes most of C-terminal ubiquitin-binding zinc finger domain. HDAC6 may have a significant role in IAV-induced apoptosis.

(http://www.ncbi.nlm.nih.gov/pubmed/19596000)