St John’s wort (Hypericum perforatum) – Triptans(sumatriptan, naratriptan, rizatriptan, zolmitriptan)
Interaction effect:
Potentiation of serotonin concentrations; increased serotonergic effects with risk of increased incidence of adverse reactions
Warning:
Stop SJW
Reference:
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & Arlett, P. St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. British Journal of Clinical Pharmacology 54 [...]
St John’s wort (Hypericum perforatum) – HIV protease inhibitors (indinavir, nelfinavir, ritonavir, saquinavir)
Interaction effect:
Induction of CYP3A4; reduced blood concentrations with possible; loss of HIV suppression
Warning:
Measure HIV RNA viral load and stop SJW
Reference:
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & Arlett, P. St John’s wort (Hypericum perforatum): drug interactions and clinical [...]
St John’s wort (Hypericum perforatum) – Combined oral contraceptive (ethinyloestradiol and desogestrel)
Interaction effect:
Breakthrough bleeding; induction of CYP1A2 and CYP3A4; reduced blood concentrations with risk of unintended pregnancy and breakthrough bleeding
Warning:
Stop SJW
Reference:
S Bon, K Hartmann and M Kuhn, Schweitzer Apothekerzeitung 16 (1999), pp. 535–536. Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & [...]
