01.11.09

Herb-Drug Internations (21)

Posted in Herb-Drug Interactions, Herbs, Weatern Herbs at 10:03 pm by Dr. Pharm Tao

Tamarind (Tamarindus indica) – Aspirin

Interaction effect:
Increased bioavailability of aspirin

Reference:
A Mustapha, IA Yakasai and IA Aguye, Effect of Tamarindus indica L on the bioavailability of aspirin in healthy human volunteers, Eur Drug Metab Pharmacokinet 21 (1996), pp. 223–226.

Turmeric – Warfarin

Interaction effect:
Potential increase in risk of bleeding

Reference:
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7.

Valerian (Valeriana officinalis) – Alcohol

Interaction effect:
A mixture of valepotriates reduces adverse effect of alcohol on concentration

Reference:
R Bos, HJ Woerdenberg, PAGM De Smet and JJC Scheffer, Valeriana species. In: PAGM De Smet, K Keller, R Hansel and RF Chandler, Editors, Adverse effects of herbal drugs 3, Springer, Berlin (1997), pp. 165–180.

Willow bark – Warfarin

Interaction effect:
Potential increase in risk of bleeding

Reference:
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7.

Yohimbine (Pausinystalia yohimbe) – Tricyclic antidepressants

Interaction effect:
Hypertension

Reference:
L Lacombiez, G Bensimon and F Isnard et al., Effect of yohimbine on blood pressure in patients with depression and orthostatic hypertension induced by clomipramine, Clin Pharmacol Ther 45 (1989), pp. 241–251.

Permalink Comments

01.10.09

Herb-Drug Interactions (20)

Posted in Herb-Drug Interactions, Herbs, Weatern Herbs at 11:30 pm by Dr. Pharm Tao

Saiboku-to (Asian herbal mixture) – Prednisolone

Interaction effect:
Increased prednisolone AUC

AUC = area under the concentration/time curve

Reference:
M Homma, K Oka and K Ikeshima et al., Different effects of traditional Chinese medicines containing similar herbal constituents on prednisolone pharmacokinetics, J Pharm Pharmacol 47 (1995), pp. 687–692.

Shankhapushpi (Ayurvedic mixed-herb syrup) – Phenytoin

Interaction effect:
Decreased phenytoin concentrations, loss of seizure control

Reference:
UP Dandekar, RS Chandra and S Dalvi et al., Analysis of clinically important interaction between phenytoin and Shankhapushpi, an Ayurvedic preparation, J Ethnopharm 35 (1992), pp. 285–288.

Sho-saiko-to or xiao chai hu tang (Asian herb mixture) – Prednisolone

Interaction effect:
Decreased AUC for prednisolone

AUC = area under the concentration/time curve

Reference:
M Homma, K Oka and K Ikeshima et al., Different effects of traditional Chinese medicines containing similar herbal constituents on prednisolone pharmacokinetics, J Pharm Pharmacol 47 (1995), pp. 687–692.

Sweet clover – Warfarin

Interaction effect:
Potential increase in risk of bleeding

Reference:
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7.

Permalink Comments

01.09.09

Herb-Drug Interactions (19)

Posted in Herb-Drug Interactions, Herbs, Weatern Herbs at 10:01 pm by Dr. Pharm Tao

Flavonol glycosides (including hyperoside) – MAO-A

Interaction effect:
Inhibition

Reference:
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & Arlett, P. St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. British Journal of Clinical Pharmacology 54 (4), 349-356.

Biflavones – Benzodiazepine receptor

Interaction effect:
Weak affinity

Reference:
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & Arlett, P. St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. British Journal of Clinical Pharmacology 54 (4), 349-356.

Xanthones – MAO-A

Interaction effect:
Inhibition

Reference:
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & Arlett, P. St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. British Journal of Clinical Pharmacology 54 (4), 349-356.

Phloroglucinols (hyperforin) – GABA receptors

Interaction effect:
Affinity

Reference:
Henderson, L., Yue, Q. Y., Bergquist, C., Gerden, B. & Arlett, P. St John’s wort (Hypericum perforatum): drug interactions and clinical outcomes. British Journal of Clinical Pharmacology 54 (4), 349-356.

Permalink Comments