Saiboku-to (Asian herbal mixture) – Prednisolone
Interaction effect:
Increased prednisolone AUC
AUC = area under the concentration/time curve
Reference:
M Homma, K Oka and K Ikeshima et al., Different effects of traditional Chinese medicines containing similar herbal constituents on prednisolone pharmacokinetics, J Pharm Pharmacol 47 (1995), pp. 687–692.
Shankhapushpi (Ayurvedic mixed-herb syrup) – Phenytoin
Interaction effect:
Decreased phenytoin concentrations, loss of seizure control
Reference:
UP Dandekar, RS Chandra and S Dalvi et al., Analysis of clinically important interaction between phenytoin and Shankhapushpi, an Ayurvedic preparation, J Ethnopharm 35 (1992), pp. 285–288.
Sho-saiko-to or xiao chai hu tang (Asian herb mixture) – Prednisolone
Interaction effect:
Decreased AUC for prednisolone
AUC = area under the concentration/time curve
Reference:
M Homma, K Oka and K Ikeshima et al., Different effects of traditional Chinese medicines containing similar herbal constituents on prednisolone pharmacokinetics, J Pharm Pharmacol 47 (1995), pp. 687–692.
Sweet clover – Warfarin
Interaction effect:
Potential increase in risk of bleeding
Reference:
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000 Jul 1;57(13):1221-7.
