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AGT (angiotensinogen (serpin peptidase inhibitor, clade A, member 8)) [ANHU, FLJ92595, FLJ97926, SERPINA8] - Hyperglycemia may be related to the adverse renal effects of angiotensin II (AII). In the kidney, the glomerular mesangial cell is the main target of AII action. Glucose augments angiotensin II-induced proinflammatory gene expression in human mesangial cells (Naito et al., 2009). AII receptor [...] AGER (advanced glycosylation end product-specific receptor) [DAMA-358M23.4, MGC22357, RAGE] - This gene belongs to the immunoglobulin superfamily of cell surface molecules (RefSeq, 2010). Higher oxidant stress and inflammation (OS/infl) have been associated with aging-related diseases and advanced glycation end products (AGEs). AGE receptor-1 (AGER1) is an antioxidant and can reduce OS/infl. Reduction of AGEs in normal diets has [...] ADORA3 (adenosine A3 receptor) [RP11-552M11.7, A3AR, AD026, bA552M11.5] This gene is a member of the family of adenosine receptors. They are G-protein-coupled receptors that are involved in intracellular signaling pathways. This gene mediates a sustained cardioprotective effect during cardiac ischemia. It is associated with the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. (RefSeq, 2010) Over-expression of [...] |
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