Infectious Diseases « Personalized, Systems, & Integrative Medicine

Selenium Deficiency and Influenza Infection

Selenium (Se) deficiency is associated with decreased activities of Se-dependent antioxidant enzymes, glutathione peroxidase (GPx) and thioredoxin reductase (TR), and with changes in the cellular redox status. Host Se deficiency is responsible for increased virulence of influenza virus in mice due to changes in the viral genome.

Se deficiency and influenza (A/Bangkok/1/79) infection may promote the activity [...]

Energy Restriction, Aging, and Influenza Infection

Energy restriction (ER) without malnutrition has been found to prolong lifespan in mice and delay age-related changes in immunity. However, aged (22 mo old) ER mice showed increased mortality, inhibited viral clearance, and decreased natural killer (NK) cell cytotoxicity after influenza A virus (H1N1, PR8) infection, in comparison with aged mice that consumed food ad libitum [...]

Antiviral Mechanisms of Flavonoids on the Inhibition of Influenza Virus Neuraminidase (NA)

Flavonoids are polyphenols. Researchers studied the structure-activity relationship (SAR) of 25 flavonoids and their effects on the neuraminidase (NA) gene of influenza virus (Liu et al., 2008). They used three typical influenza virus strains A/PR/8/34 (H1N1), A/Jinan/15/90 (H3N2), and B/Jiangshu/10/2003.

The researchers observed that the order of inhibition potency on NA by flavonoids was auronesm greater than [...]

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Selenium Deficiency and Influenza Infection

Energy Restriction, Aging, and Influenza Infection

Antiviral Mechanisms of Flavonoids on the Inhibition of Influenza Virus Neuraminidase (NA)

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